Inovio

The state of the fight: 

A slew of vaccine manufacturers announced plans to tackle the Omicron variant.
  Aspen Pharmacare and J&J neared a deal that would let the South African manufacturer market its own version of the Janssen shot.
  Gavi’s board approved the alliance’s COVAX strategy for 2022.

AUTHORIZED VACCINES  


New research on the Pfizer/BioNTech shot affirmed its efficacy in younger people and its safety in older people.
 

The University of Oxford has launched a Phase 1 trial of a multivalent Ebola vaccine candidate targeting both the Zaire and Sudan strains of the filovirus, the university announced last week.

The ChAdOx1 biEBOV vaccine uses the same adenovirus vector platform as the AstraZeneca/Oxford Covid-19 shot, whose storage conditions are “amenable to use in the developing world,” the trial’s chief investigator noted. By contrast, Merck’s Ebola vaccine, Ervebo, requires ultracold storage.

The state of the fight: 

More European countries cautioned against Moderna’s vaccine for younger people over concerns about side effects.
  Generics companies are preparing to roll out their versions of Merck’s molnupiravir oral antiviral.
  Pfizer is in talks with 90 countries over supply deals for its antiviral candidate.

 

AUTHORIZED VACCINES  


France and Germany recommended against the Moderna vaccine for people under 30 over concerns about…

The state of the fight: 

WHO issued an Emergency Use Listing for Bharat Biotech’s Covaxin vaccine.
  Kenya’s Revital Healthcare will more than triple its annual syringe production amid a “looming shortfall” in LMICs.
  Pfizer’s Paxlovid antiviral slashed Covid-19 hospitalizations or death by 89%.

 

AUTHORIZED VACCINES

 
WHO listed Bharat Biotech’s Covaxin vaccine for emergency use on Wednesday, citing 78% efficacy against Covid-19 of any severity…

The state of the fight: 

A U.S. FDA advisory panel recommended booster shots of the J&J and Moderna vaccines for select groups.
  CureVac will abandon development of its first-generation mRNA-based vaccine candidate.
  Brii Bio has submitted its monoclonal antibody cocktail to the U.S. FDA for Emergency Use Authorization. Approved or authorized vaccines

 
WHO advisory group backs extra dose for immunocompromised: WHO’s Strategic Advisory Group of Experts (…

The state of the fight: 

CanSino and Pfizer/BioNTech released positive news on their respective vaccines in children.
  WHO added Regeneron and Roche’s monoclonal antibody cocktail to its list of recommended therapeutics.
  California’s NantWorks plans a $200M investment to produce Covid-19 and other vaccines in South Africa. Approved or authorized vaccines

 
Pfizer and BioNTech touted positive topline results from a Phase 2/3 trial in children ages 5-11 of…

The state of the fight: 

Pfizer/BioNTech’s Comirnaty became the first Covid-19 vaccine to earn full U.S. FDA approval.
  China authorized booster doses for those at high risk of contracting Covid-19.
  Brazil’s Eurofarma Laboratórios will produce Pfizer/BioNTech’s vaccine for exclusive distribution in Latin America.

 

Approved or authorized vaccines

 
British study sees waning protection from shots: The app-based ZOE COVID study (led by a Kings College…

The state of the fight: 

Zydus Cadila’s three-dose, needle-free ZyCoV-D became the first authorized DNA-based Covid-19 vaccine.
  AstraZeneca’s AZD7442 long-acting antibody reduced infection risk by 77% in Phase 3.
  PAHO’s Revolving Fund will begin procuring Covid-19 vaccines for member states. Approved or authorized vaccines

 
Assessing antibody levels to predict Moderna’s effectiveness: Researchers at Seattle’s Fred Hutchinson Cancer Research Center announced…

Inovio announced last week that it has dosed the first participant in a Phase 2 study of its INO-4700 DNA vaccine against MERS. The multicenter trial—funded by the Coalition for Epidemic Preparedness Innovations (CEPI)—will involve approximately 500 healthy adults in Jordan and Lebanon.

According to the press release, Inovio and CEPI plan to make a stockpile of INO-4700 “available for emergency use as soon as possible following Phase 2 testing.”

Mentions:

Advaccine has dosed the first participants in a Phase 2 study of ADV110, its adjuvanted protein subunit RSV vaccine candidate, the Chinese company announced last week.

In other news, the company will collaborate with Inovio on a global Phase 3 trial of the Pennsylvania-based company’s DNA Covid-19 vaccine candidate, INO-4800, under an expanded tie-up announced Tuesday.